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  • The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) greater than 27, given that they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had an average weight loss of four years old.1% rather than participants who were given placebos) throughout a 12- month period, while a different study involving patients with diabetes type 2 had a typical weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to lose weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the those who go through it you ought to err to the side of caution and allow FDA do its job and demand some study be done in order that the public understands the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on his or her medications.

    Researchers discovered that participants taking this drug for the year, dropped a few pounds within a month and have kept the body weight off during the entire 56 weeks of the study. Contrave is a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of many active ingredient, which may make them far better and safer.

    Combo-pilling may be the newest fad or also the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that as of right now there aren't any long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug may also raise blood pressure levels and heartbeat, and mustn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

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